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The LINCS algorithm (73) was used to constrain all the bonds involving hydrogen atoms to their equilibrium distance

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Our findings suggest that the novel hub gene GPX3 is involved in the neutrophil-driven oxidative stress-mediated pathogenesis of RA

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Grx plays a multifaceted role, controlling the cell cycle through the p53/p21/p16 signaling pathway and protecting against oxidative stress by modulating the Akt kinase-forkhead box O1 (Akt-FoxO1), c-Jun N-terminal kinase (JNK), and nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-B) signaling pathways [76,77,78]