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Autophagy in cardiovascular aging

Exosomes naturally overcome BBB barriers through specific translocation mechanisms, making them a compelling vehicle for targeted brain therapies

Lin SH, Raju GS, Huff C, Ye Y, Gu J, Chen JS, Hildebrandt MAT, Liang H, Menter DG, Morris J, Hawk E, Stroehlein JR, Futreal A, Kopetz S , Mishra L, Wu X

Additionally, PAR2-dependent signaling has been implicated in promoting weight gain and metabolic inflammation in mouse models of diet-induced obesity (DIO) (23), but the specific proteases by which PAR2 signaling exerts metabolic inflammation and DIO remain unclear (24)