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adults The impact on absorption is usually minimal but is unpredictable Activity equivalent to adults is typically achieved by 2 years of age Developmental Pharmacology: GI Absorption Activity of Intestinal drug metabolizing enzymes CYP3A4/5, CYP1A, N-acetyltransferase, xanthine oxide, glutathione-S-transferase And transporters P-glycoprotein, organic anion, and cation transporters Reach adult levels between ages 6 and 12 months Developmental Pharmacology: Skin Absorption Percutaneous absorption Directly related to the degree of skin hydration