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Polyamine catabolism, mediated by intracellular enzymes such as spermidine/spermine N 1 -acetyltransferase 1 (SAT1, also known as diamine acetyltransferase 1), polyamine oxidases, and spermine oxidase (SMOX), yields toxic metabolites including acrolein and hydrogen peroxide that may drive cell death 25,26,27,28,29

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Zeisel 1 , (1)Cancer Research Center of Lyon (CRCL), Umr Inserm 1052 Cnrs 5286 Mixte Clb, Universit Lyon 1 (UCBL1), (2)Department of Hepatology, Croix Rousse Hospital, Hospices Civils De Lyon, France Background: Enhancer of Zeste Homolog 2 (Ezh2) is frequently upregulated in hepatocellular carcinoma (HCC) tissues and increased Ezh2 expression correlates with HCC aggressiveness and/or poor prognosis

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