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In general, stabilization of HIF and an increase in its hyper-inflammatory activity occur with loss or dysfunctional protective action of the cellular Sirtuins

Moreover, according to this model GluN1-S773 might be interacting with two EAR-20 residues, Glutamine 9 (Gln 9) and Glutamate 7 (Glu 7) by means of 4 different hydrogen bonds

doi:10.1111/fcp.12166 184

Geographical disparities in pooled stroke incidence and case fatality in mainland China, Hong Kong, and Macao: protocol for a systematic review and meta-analysis