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In PEM, there are insufficient building blocks and energy to make immune cells and immune factors that protect the body from infection and disease

However, despite the complex interplay between coagulation and inflammation, activation of coagulation is not a prerequisite for cell injury or organ damage [22]

doi: 10.1016/j.reprotox.2020.06.012 22 WuWChenYGuoWZhangKChenWFuMet al

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These effects are primarily associated with protecting SAA metabolism from oxidative stress, inhibiting NF-B and NLRP3 inflammasome activity, regulating energy metabolism, and mitigating ER stress and apoptosis (Figure 2)