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Hepatol Int 17 , 522541 (2023)

Furthermore, considering the high recurrence rate following surgical resection, localized postoperative interventions capable of eliminating residual tumor cells and reprogramming the tumor bed are highly desirable [15, 16]

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One of the frequent epigenetic alterations in hepatocellular carcinoma (HCC) is hypermethylation of the promoters of the Secreted Frizzled-Related Protein (SFRP) gene family, which is a key component in the regulation of the Wnt/ -catenin signaling pathway

R.LuW.GrabockaE.et al (2015)

doi: 10.2337/db22-0623