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Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications

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In laboratory settings, GHK-Cu is used to investigate copper-binding mechanisms, peptidemetal interactions, and regulatory biochemical pathways in controlled experimental models

429,430,431,432,433 The mechanism of enhanced glycolysis involves the activation of pyruvate kinase isoenzyme M2 (PKM2), which triggers downstream inflammatory factors in a hypoxia-inducible factor 1 (HIF-1)-dependent manner

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