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Third, our immune profiling was limited to broad lymphocyte categories, warranting more detailed phenotyping (e.g., Tregs, Th17) and functional assays

doi: 10.1111/febs.16272 180 LiuHTangJDuYSaadaneASamuelsIVeenstraAet al

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The extracts also suppressed the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1) (282)

These toxins can disrupt the MTHFR pathway, contributing to increased toxic burden and impaired detoxification capabilities