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In RH13.1, the register of the strand pairing is shifted by a cross-strand hydrogen bond from an aspartic acid sidechain to a backbone amide nitrogen, creating a twisted -sheet cyclized at two ends by a type I turn and an turn, and further stabilized by hydrophobic interactions between the nonpolar sidechains (Fig

No mice were excluded from statistical analysis

However, the metabolites in the GSH synthesis, export and reimport pathway decline very slowly, achieving their new steady states in 45 days (data not shown)

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