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The recommended daily dose of vitamin B12 for adults is 2.4 micrograms, but higher doses have been shown to be safe

596 The simultaneous effects of impaired NAD + biosynthesis and over depletion of NAD + by PARPs can lead to a decrease in the level of NAD + in the kidney during AKI

La posologie de Vitamine B12 Gerda devra aussi tre adapte en fonction de l'intensit de la carence : Une posologie par voie orale de 4 000 g (durant les 2 premiers trimestres de la grossesse) et 5 000 g (durant le 3me trimestre et l'allaitement) tous les 15 jours chez les femmes enceintes ou allaitantes ayant un apport en vitamine B12 insuffisant