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AM-36 is a neuroprotective agent that combines antioxidant and Na + channel blockade properties ( 3.2 Parkinsons disease Parkinsons disease (PD) is a common neurodegenerative condition distinguished by the progressive degeneration of dopaminergic cells in the substantia nigra, a region in the midbrain known for its accumulation of synuclein (Poewe et al., 2017)