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This depletion occurs because, during its metabolism, paracetamol produces a toxic metabolite that is normally detoxified by glutathione

doi: 10.1038/npp.2011.109

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In the carbon-1 position, fatty acids nearly always are fully saturated, i.e., contain no double bonds, whereas the acyl chains esterified to the carbon-2 position of glycerol nearly always are unsaturated

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