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Dissolution is an extrinsic property affecting a wide range of chemical, physical and crystallographic factors including complexation, particle size, surface properties, and modifications to the solid-state or formulation strategies that improve solubility

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Goodacre A, Engel H, Kleine HD, Walker S, Cork A, Seong D, Siciliano M, Andreeff M

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Crit Care Med 1993;21:1635-42