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Overall, the available data support a cautious model in which mitochondria in the apical domain of PACs function as local ATP suppliers and Ca 2+ buffers that help maintain the secretory apparatus under physiological conditions, whereas mitochondrial failure in AP may indirectly destabilize the granule-rich apical region and facilitate pathological zymogen activation

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Yushmanov, V.E., Perussi, J.R., Imasato, A.C., Rugiero, M

This 60% decline correlates with reduced wound healing, skin thinning, and hair follicle miniaturisation

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