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Genetic variants in the AOC1 gene (encoding the DAO enzyme) and the HNMT gene are the primary genetic factors

Cordeiro S, Silva B, Martins AM, Ribeiro HM, Gonalves L, Marto J

Oncologist 2013, 18, 11901191

doi: 10.1016/j.livsci.2007.01.159 31 BeutlerB

3.1.5 HIF-1 and HIF-2 HIF-1 and 2 are TFs, playing a significant role in proliferation, oxidative stress, inflammation, and apoptosis, by binding to its hypoxia response elements (HRE) on the promoter region of its target genes under hypoxic or toxic conditions ( 3.1.6 NF-B NF-B, a master regulator of genes involved in cytokine production and cell survival, plays an important role in Mn-induced neurotoxicity (for review, see Pajarillo et al., 2021)

Seminars in Perinatology