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Mitochondrial complex I deficiency caused by a deleterious NDUFA11 mutation

Oxidative stress causes mitochondrial damage, which in turn results in more damage to astrocytes than to neurons

Additionally, regular vet check-ups can help catch any deficiencies early on

However, during the seizure, the voltage-gated potassium channels (Kv) fail to efflux enough K + ions out of the cell to maintain a normal level of ions inside the cell, which causes an imbalance of the action potential and again leads to the disturbance of excitatory and inhibitory cycle of the neurons and finally develops seizure (Gao et al., 2022)

Molecular Characterization of the Cystine/glutamate Exchanger and the Excitatory Amino Acid Transporters in the Rat Lens

Pulmonary artery pressure (PAP) markedly increases in this condition