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To prevent nerve root edema and irritation after PPECD and avoid the risk of total spinal anesthesia (TSA) and spinal cord injury, epidural administration is not available [19, 20]

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198 Collectively, these factors result in inconsistent exposure of dendritic cells and tumor cells to ICD inducers or adjuvants, limiting the potency and reproducibility of in situ cancer vaccination across patients and tumor lesions