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But an opposite trend was detected in the structural abnormalities caused by the severity of nicotine dependence, and smokers with moderate nicotine dependence were found with severe brain region atrophy in comparison to smokers with severe nicotine dependence, especially in GM areas of precuneus, superior and MTG, middle occipital gyrus, posterior cingulate and insula, and in WM areas of precuneus, posterior cingulate, cerebellum anterior lobe and midbrain ( Table 5 )

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