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Carnitine could be involved, since the carnitine content in the tissue decreases with age, thereby reducing the integrity of the mitochondrial membrane

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No significant effects were observed upon treatment with MAGE-A4-TCB (without and with IFN-) when compared with the non-targeted DP47-TCB, while the positive control ESK-1TCB triggered significant target cell lysis, cytokine release and T-cell activation/proliferation in all 2D/3D in vitro systems evaluated, from the lowest concentrations and the earliest time point evaluated

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Using a cell permeable dye, TMR-Star, we observed a diffuse distribution of HMW-SLP-SNAP throughout the cell (Fig