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The photostimulation of KR can indirectly lead to mitochondrial elongation rather than through a ROS-mediated mechanism by depolarizing the inner-mitochondrial membrane

This is why its impossible to overdose

10.1002/acn3.725 Ann

Polymers including polyethylene glycol (PEG), polyethylenimine (PEI) and chitosan have been demonstrated to be excellent surface coating agents for MSNs, which can significantly improve the in vivo circulation time, reduce cytotoxicity and hemolytic effect of MSNs

Autoimmun Rev 8:287291 Lu Z, Xu S (2006) ERK1/2 MAP kinases in cell survival and apoptosis

However, when ER stress is excessive and/or prolonged, the UPR initiates apoptotic processes (57)