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Reported side effects in human anecdotal use are generally mild and may include: Mild nausea, particularly with oral administration Redness, itching, or irritation at the injection site Temporary dizziness or mild headache Changes in appetite or weight A significant theoretical concern revolves around its pro-angiogenic properties

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This is particularly relevant because hypoxic tumours are known to exhibit increased resistance to radiotherapy and certain systemic therapies (190, 191), and therefore, imaging hypoxia has potential implications for treatment planning and prognostic assessment

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