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Saunders, Sarah Soden, Angela J

In MASLD, fat accumulation and oxidative stress in the liver lead to the activation of Kupffer cells

Overdose can cause hypotension, tachycardia, seizures, paralysis and coma

For Rho-GTP staining, fixation was performed with ice-cold 10% trichloroacetic acid (TCA) in water for 15 min followed by a 20-min extraction in ice-cold 0.2% Triton X-100

As a consequence, after 24 h of administration, drug-loaded NPs accumulated mainly in tumor tissues, with a minor accumulation in other organs, and the tumors in the drug-loaded NP groups almost completely disappeared after 14 days [196]