glutathione synthetase deficiency usmle HMP Shunt - Biochemistry A very common USMLE Step

A very common USMLE Step 2 CK trap macrocytic anemia in alcohol use, and many jump to the wrong deficiency. Chronic alcohol use + macrocytosis pancytopenia think folate Glutathione synthetase deficiency MedLink Neurology X linked recessive NADPH RBCs can't handle oxidative stress NADPH keeps glutathione active protects RBCs Triggers ( Biochemical pathway and lab findings of 21 hydroxylase deficiency USMLE #USMLEStep1 #MedEd #Endocrinology #Pediatrics #CAH #AdrenalHyperplasia #Genetics #Step1Prep #HighYield #MedSchool #InternalMedicine #Biochemistry #Steroidogenesis #FutureDoctor Glucose 6 phosphate dehydrogenase (G6PD) deficiency: Video Osmosis These USMLE Step 2 CK nutrition questions are classic pattern recognition once you see the combo, the answer should be instant. Vitamin A deficiency Think: photophobia + dry eyes (xerosis) +

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