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Activated hepatic stellate cells (HSCs) play critical roles in various biological processes

Data extraction and synthesis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure methodological transparency and rigor

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Studies document effects on 31.2% of human genes (approximately 4,000+ genes) with 50% expression change, suppressing RNA production in 70% of 54 genes overexpressed in metastatic colon cancer

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