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Within this therapeutic agent, the Pt nanoparticle catalyzes the decomposition of UA and actively breaks down endogenous hydrogen peroxide (H 2 O 2 ) to produce O 2 , which helps to alleviate hypoxic conditions

This has given rise to the concept of a therapeutic window, which is a range of doses or blood/plasma concentrations within which most individuals should show a beneficial response with minimal risk of adverse effects (illustrated by response 1 in Fig

The oxidative stress is in terms of serum lipid peroxidase level and antioxidant activity in terms of superoxide dismutase and glutathione peroxidase levels were compared in type II Diabetes mellitus and age matched healthy controls

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