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In a study of patients with chronic low back pain, Vitamin B12 given for 2 weeks reduced pain by 32% compared to placebo [Chiu, 2011] In a 2020 systematic review looking at the use of B12 for nerve-related pain it was found that there is moderate evidence for the therapeutic effect of B12 in the treatment painful peripheral neuropathy [Julian, 2020]

Immunoblots of ZSWIM8 protein variants are shown in Supplementary Fig

PMID: 39310099 Cell Death Dis Astrocytic YAP prevents the glutamate neurotoxicity by upregulation of EAAT2 expression and promotes the gain of stemness in astrocytes in ischemic stroke mice

doi: 10.1016/s0167-5273(02)00243-7

This attention to detail is for researchers in controlled lab settings

However, other circumstances can also be responsible, such as viral pneumonia, sepsis, chest injuries, burns, blood transfusions, aspiration of gastric contents, pancreatitis, intravenous drug use, abdominal trauma, and acute radiation syndrome [165167]