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2.2 High-fidelity mouse models were used for testing combinatorial inhibitor therapy Like studies in melanoma, where BRAF inhibitor monotherapy shows rapid but transient MAPK pathway inhibition, PLX4720 treatment in glioma cell lines (M-38, DBTRG-05MG and NMC-G1) did not suppress MAPK pathway signaling in a durable way

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However, neither our AP-day nor AP-life drug exposure measures contributed to the phase-related reduction in dACC glutamate in our mediation analysis (Fig

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