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Shift gradually if crossing more than six time zones: move dosing time forward or backward by two hours per day until you reach the new local morning window

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The inclusion of such references -the literature of the 90's offers a vast choice- would further help the reader, in addition to the indications mentioned in the text about the respective proportion of neurons expressing TrkB and TrkA: the survival promoting activity of BDNF is quite modest for DRG compared with NGF, but this the opposite for some cranial sensory ganglia

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In summary, the CPZ model has been shown to mimic many aspects of human demyelinating diseases such as MS, and to be a useful experimental approach to study these diseases and test potential therapies, especially after its standardization on C57BL/6 mice (Vega-Riquer et al., 2019