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Funding This study was supported by the State Key Laboratory of Trauma, Burn and Combined Injury (SKLYQ202002 to YC), Southwest Hospital (SWH2018BJKJ-05 to YC), National Natural Science Foundation of China (82030036 to HF), and Chongqing Talent Program (4139Z2391 to HF)

**Patch Test:** Before applying to your entire face, perform a patch test on a small, inconspicuous area of your skin (e.g., behind the ear or on the inner forearm), and wait 24 hours to check for any adverse reactions

It covers only the administration service, not the medication itself

10.1007/s00284-022-02825-5 103

Nature 477 , 9094 (2011)

Personalization in Timing The best time for you depends on your specific health goals and lifestyle: For Active Lifestyles: If you need sustained energy for physical or mental tasks, the morning is likely best