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Consistent with these in vitro findings, co-immunoprecipitation assays in G2-synchronized HeLa cells revealed that Myc-tagged Pds5B associated with wild-type Sororin-GFP, but not with the phospho-mimetic Sororin-S145E-GFP mutant (Supplementary Fig

By integrating autophagy regulation with drug intervention, we can disrupt the favorable conditions autophagy provides for malignant cells, and circumvent its metabolic reprogramming adaptation strategy, thereby enhancing the sensitivity of AML cells to existing treatments

Biomarker performance was evaluated using receiver operating characteristic (ROC) curve analysis based on exploratory multivariate models, calculating area under the curve (AUC), sensitivity, and specificity

Lands LC, Grey VL, Smountas AA: Effect of supplementation with a cysteine donor on muscular performance

These transform ribulose 5-phosphate into: ribose 5-phosphate, and xylulose 5-phosphate, respectively

Any level of IOP can contribute to pathology but the risk for contracting glaucoma increases exponentially when chronic IOP exceeds 20 mm Hg (Figure 8)