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Selenium in intensive care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock

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After 8-12 weeks of consistent use, evaluating response allows informed adjustments that optimize outcomes while minimizing unnecessary exposure or expense

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At this time point, however, whether the microbiome alterations documented in SSc are primary or secondary to organ pathology and/or medication use is not yet established