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But with the evidence from new investigation which reported that cancer cells not only have acidic environment but also alkaline has limited the applications of pH sensitive nano drug carriers

With expanding knowledge of the acetylation regulatory network and improvements in tailored intervention technologies, new methods to modify acetylation changes may provide treatment options for patients with HCC

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However, -synuclein that is phosphorylated at serine 129 as appears in Lewy Bodies in Parkinson's disease, and -synuclein that is mutated in familial Parkinson's disease cannot be degraded by chaperone-mediated autophagy [10], and is thus presumably highly sensitive to blockade of macroautophagy

Continued studies are necessary to elucidate their mechanisms and optimize their application in personalized medicine