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47,59-62 Given that N 2 O can be used during spine surgery, this points to the necessity of routinely monitoring B 12 levels in patients with DCM to optimize surgical outcomes and prevent perioperative or postoperative neurological deficit development

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In this regard, it is interesting that IgG antibodies that show similar FcRn binding properties can have variable plasma half-lives due to differences in biophysical properties, such as pI and net charge, which affect cellular handling 83,84,85,86,87