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198 These findings underscore the intricate role of lactate and lactylation in the tumor microenvironment, influencing immune surveillance, immunosuppression, tumor behavior, and therapy response

8 Modafinil has been studied in RCTs and was associated with improvements in fatigue in people with MS

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The stabilization of HIF1 leads to the up-regulation of HIF1 target pyruvate dehydrogenase kinase-1 (PDK1), which phosphorylates and inhibits activity of pyruvate dehydrogenase, an enzyme involved in TCA

In a large series cancer was seen in 21% among 349 patients with inflammatory myopathies