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Ma GY, et al

Reference: Schijns W, Homan J, van der Meer L, Janssen IMC, van Laarhoven CJHM, Berends FJ, Aarts EO

The compound was selected from a series of quinolinium-based molecules studied for cell permeability, enzyme selectivity and inhibition of NNMT

By injecting melanoma cells into CD38/ mice, the function of CD38 could be studied and was found to be involved in (1) resistance to cell death, (2) tumor vascularization through a reduction in CD34, (3) recruitment of CAFs and (4) metastatic properties [50]

As seen below, two of the peptides have been prohibited by the World Anti-Doping Agency

DFT calculations indicated that CaT was stable at room temperature