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Importantly, this regulation cascade can be exploited by targeting YBX1 to block AMPK protein synthesis and targeting GLUT1 to induce energy stress, which synergistically blunts tumor growth in vivo

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After verifying oxidizing influences on Mia40 in vivo , we next wanted to test which reducing pathways act on Mia40 or more specifically whether the redox state of Mia40 is susceptible to changes in E GSH (Figure 8A)

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typhimurium - or acetaminophen-induced liver failure with equal dose, both of which induce liver failure independent of GSDME

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