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Antioxidants 9, 700722

The duration of the chemotherapy treatment is another possible risk factor for CIPN

Genome-wide profiling of DNA methylation reveals transposon targets of CHROMOMETHYLASE3

Under stress such as amino acid deprivation or oxidative condition, NRF2 migrates to the nucleus to initiate transcription of the antioxidant response element (ARE)-containing genes via disassociation from KEAP1 [78]

Given the central role of ROS homeostasis in health and disease, targeting ROS and their mediated ROS balancing pathways holds great therapeutic potential [556, 557]