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NO-releasing agents, such as JS-K ( O 2 -(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) 123 and PABA/NO ( O 2 -[2,4-dinitro-5-( N -methyl- N -4 carboxyphenylamino)phenyl] 1- N , N -dimethylamino)diazen-1-ium-1,2-diolate) 124 , are able to induce differentiation and cell death in a variety of cancer cells through GSH consumption, DNA synthesis inhibition and inhibition of enzymes involved in the defense against cell damage

doi: 10.1128/CMR.18.1.44-69.2005 156 CahillBCHibbsJRSavikKJuniBADoslandBMEdin-StibbeCet al

Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, Ganie SA (2015) Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases

Jeanes YM, Reeves S

However, topical nanotechnology-based formulations seem to possess a presumed ability to surmount the above-mentioned limitations

En las clulas, trabaja en conjunto con otras molculas, especialmente las vitaminas C y E