chac1 glutathione L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated degradation in hepatocellular carcinoma Dysregulated lipids homeostasis disrupts CHAC1-mediated

Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect Frontiers The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element* Journal of Biological Chemistry BACH1CHAC1Glutathione Axis Aggravates Myocardial IschemiaReperfusion Injury by Enhancing Ferroptosis and Oxidative Stress Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC Nature Communications

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