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Contraction of the ciliary muscle facilitates opening of the trabecular meshwork via the scleral spur, thereby increasing aqueous humor outflow and reducing IOP, while pupillary constriction can contribute to angle opening in eyes with narrow or occludable angles

Oral BPC-157 capsules Standard oral capsules: Contains BPC-157 powder Take on empty stomach Lower bioavailability (only small amount absorbed) Works directly on stomach/gut lining as it passes through Dosing: 500-1,000mcg daily (higher than injectable due to poor absorption) Split into 1-2 doses Take 30 minutes before meals Best for: Stomach ulcers IBS and digestive issues Leaky gut Esophageal issues Oral stable BPC-157 (Arginate or Acetate) Better oral absorption: BPC-157 Arginate or BPC-157 Acetate Modified to resist stomach acid breakdown Higher bioavailability than standard oral More expensive Dosing: 250-500mcg daily (similar to injectable) Can work systemically when absorbed Still best for gut issues How to take: Empty stomach preferred 30 minutes before food With water Don't take with acidic beverages Sublingual administration (under tongue) Some users try sublingual: Hold under tongue for 60-90 seconds May improve absorption vs swallowing No definitive evidence it's better Worth trying if you have capsules How to do it: Open capsule Pour powder under tongue Hold as long as possible Swallow saliva after 60-90 seconds BPC-157 dosing protocols by condition How much to take depends on what you're treating

Annu Rev Physiol (2021) 83:30330

V.VormfeldeS

Solid lipid nanoparticles: a potential approach for dermal drug delivery

A few commenters suggested a period of confidential reporting to facilitate iterative improvement