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The rs12720356 (I684S) and rs3456443 (P1104A) have also been implicated in T1D and other autoimmune diseases, including psoriasis, rheumatoid arthritis, and Crohns disease (121)

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Numerous mechanisms cause AKI, including prolonged organ underperfusion, systemic wasting disorders, toxins, infections, and severe forms of primary glomerular disease (Missailidis et al., 2016)