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In another study, also by Professor Sinclairs group, a 1-week (500 mg/kg/d i.p.) intervention with NMN was found to enhance the oxidative metabolic capacity of mitochondria in the skeletal muscles of elderly mice

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A high fat diet (HFD) promotes gut leakiness through dysbiosis, since antibiotic treatment has been shown to be effective in improving intestinal permeability and glucose homeostasis in HFD-fed mice [128]

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pylori adapting to the acidic gastric environment, releasing adhesion factors that bind to epithelial cells, and subsequently secreting toxin proteins, thereby establishing a persistent infection (Figure 3)

In the same model it was found that treatment increased responses to polyinosinic:polycytidylic acid (poly I:C), an antiviral ligand, and type I interferons, further supporting the antiviral properties of vitamin C in airway cells and potentially providing a way to combat air pollution-induced dysregulation of antiviral immune responses