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[39] What this means is that, disruptions that occur to the gut (for instance, from taking an antibiotic, taking acid-suppressing medications for acid reflux , or eating an inflammatory food like gluten ), can upset the microbiome, cause intestinal permeability ( leaky gut ), and result in a shared gut-brain inflammatory event

During the periconceptional period and early pregnancy, adequate folate is critical for neural tube closure (which occurs in the first 28 days of pregnancy, often before a woman knows she's pregnant), for supporting rapid cellular division in the developing embryo, and for normal placental development

PMID 24607292

1998 Dec;23(12):1485-91

Cipolli, C