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Apart from this, research over the years has also reported the complex interplay of probiotics and their metabolites in the modulation of PI3K/Akt/mechanistic target of rapamycin kinase (mTOR) signalling pathways, which is one of the dysregulated pathways in various cancers, including brain cancers [49, 270, 271]

Studies in vitro and ex vivo using primary fibrotic mouse alveolar epithelial type II and primary human fibroblasts demonstrated that treatment with this senolytic combination attenuates fibrotic mediator expression, such as senescence-associated secretory phenotype factor and extracellular matrix markers (Lehmann et al., 2017