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Figure 2 2.1.1 Effects on innate immune system Neutrophils are the most abundant leukocytes population in peripheral blood, and they exert their activity early during inflammation, releasing cytokines, proteases, producing reactive oxygen species (ROS), and creating neutrophils extracellular traps (NETs) (33) Neutrophils represent the main targets of A1AT action: being an anti-protease, its primary effect is to inhibit serine proteases deriving from degranulating neutrophils including NE, cathepsin G and PR3 (34)

Oxygen conditions oscillating between hypoxia and hyperoxia induce different effects in the pulmonary endothelium compared to constant oxygen conditions

Au et al., 2022b)

Fan Y, Su Q, Chen J, Wang Y, He S

Martinez FD, Antognoni G, Macri F, Bonci E, Midulla F, De Castro G, & Ronchetti R (1988) Parental smoking enhances bronchial responsiveness in nine-year-old children

Piezo1 expression in neutrophils regulates shear-induced NETosis