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This establishes a direct and important mechanistic bridge between the classic mechanical pathogenic factor in OA and the emerging oxidative stress-mediated cell death pathway

Iron infusions are generally very well tolerated

Chetlin RD, Yeater RA, Ullrich IH, Hornsby WG, Malanga CJ, Byrner RW

Canty et al., While NAC has been used for decades as a strong antioxidant, the actual mechanism of its antioxidant effect is not fully clear

However, current hepcidin or minihepcidins alternative strategies require parenteral administration

Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of Malignant lymphoma in primary Sjgrens syndrome