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Acupuncture shows potential in ME/CFS management through its ability to activate the vagus nerve, reduce pro-inflammatory cytokines, polarize immune cells toward an anti-inflammatory state, and inhibit critical inflammatory signaling pathways [177, 178]

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The activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) constitute a first-line antioxidant defense system that plays a key and fundamental role in the total defense mechanisms and strategies in biological systems 81

For instance, butyrate enhances astrocytic neurotrophic support, promoting slow-wave sleep and cognitive function [113,114,115,116]

albicans exhibits a unique hybrid epigenetic feature with characteristics of both euchromatin and heterochromatin, which not only ensures the stability and normal function of centromeres during fungal cell division, but also regulates genome plasticity and expression of adjacent virulence-related genes, thereby playing an essential role in mediating the adaptability and pathogenicity of C

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