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3) Glycaemic and cardiometabolic endpoints in defined populations Some cagrilintide combination studies include participants with type 2 diabetes and report glycaemic endpoints such as HbA1c alongside weight change

The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway and involves selective degradation of their C-terminal region containing ankyrin repeats

Immunosuppressants (tacrolimus, mycophenolate) : GI side effects reduce intake

Transgenic murine models for cognition Beyond chemical lesion models (scopolamine, 192-IgG-saporin), cognitive research has an arsenal of genetically modified strains that reproduce specific cognitive phenotypes: Alzheimer models 3xTg-AD (LaFerla): triple transgenic APP Swedish, PS1 M146V, tau P301L

In Rac1 conditional KO mice where Rac1 was deleted in mature neurons, working memory in the delayed matching-to-place (DMP) water maze test was impaired (Haditsch et al., 2009), implicating Rac1 in memory acquisition but not in memory consolidation

Quantitative real-time imaging of glutathione with subcellular resolution