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So far, many IKK inhibitors displayed significant therapeutic effects in pre-clinical animal experiments, and some inhibitors, such as MLN-120B, IMD-2560, and SAR-113945, have finished the phase I or II clinical trial for the safety, tolerability, and pharmacokinetics

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Preclinical and phase 1 assessment of antisense oligonucleotide bepirovirsen in hepatitis B virustransgenic mice and healthy human volunteers: support for clinical dose selection and evaluation of safety, tolerability, and pharmacokinetics of single and multiple doses

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Conflicts of interest The authors have no conflicts of interest to declare